10 Unusual Skin Problems That Could Be a Sign of a Serious Disease

SCOTT LEMAN/SHUTTERSTOCK

There are tender red bumps under your skin

While the gut and skin may not seem all that connected, they are. Inflammatory conditions like irritable bowel disease (IBD) can show up on your skin. Painful red nodules may appear on your legs; they’ll also feel deep in the surface of the skin, explains Dr. Reynolds.

The condition is called erythema nodosum and may appear during a flare-up of symptoms, such as persistent diarrhea or bloody stool.

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