16 Negative Effects of Caffeine on Your Body

Irritability: When your body is used to caffeine, you can experience irritability as a symptom of withdrawal.
Decreased risk of oral cancer: Drinking four or more 8-ounce cups of caffeinated coffee may lower your risk of oral and throat cancers.
Rapid heartbeat: Caffeine can cause a rapid heartbeat. This may be a concern if you have a preexisting heart issue. You may notice arrhythmias whenever you have caffeine.
Heartburn: The acidity of certain caffeinated products, such as coffee and soda, may cause heartburn.

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